Effect of surface electric-impulse stimulation on cardiac electrical activity of Kunming mice

doi:10.3969/j.issn.2095-4344.2014.27.010

Abstract

Abstract:

BACKGROUND: Electrical stimulation at different intensity, frequency and time on the human body may produce a variety of pathophysiological reactions.
OBJECTIVE: To observe the effects of surface electric-impulse stimulation on heart rhythm and heart rate in mice.
METHODS: Thirty Kunming mice were randomly divided into three groups, each group contained 10 mice. Electrical stimulation at different voltage, time and frequency was respectively applied to the three groups. The stimulus power was supplied by BL-420F Data Acquisition & Analysis System. The II lead electrocardiogram was recorded. The systemic reactions and local body changes of mice were observed.
RESULTS AND CONCLUSION: Electrical stimulation at the voltage less than or equal to 10 V had no effect on heart rate, and there was no arrhythmia. When the voltage was greater than or equal to 15 V, electrical stimulation slowed down heart rate, which was restored to normal 30 minutes later. When the voltage was greater than or equal to 35 V, arrhythmia and slow heart rate occurred in mice, and the heart rate can not get back to normal. Also, some mice got ventricular fibrillation after electrical stimulation at the voltage greater than 75 V. However, when voltage was equal to 10 V, the effect of electrical stimulation at different frequency or time on cardiac electrical activity was not significant. The effect of electric-impulse stimulation by body surface on heart rhythm and heart rate in mice mainly depends on the discretion of electrical stimulation voltage. Less than or equal to 10 V, electric-impulse stimulation has no effect on heart rhythm and heart rate; the frequency or time of electric-impulse stimulation almost has no significantly effect on heart rhythm and heart rate in mice.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: pulse therapy, drugs, electric stimulation, electrocardiography, arrhythmias, cardiac

CLC Number:

R318

Li Yong-lin, Zhang Hui, Shi Ruo-fei, Tang Xiao-man, Xie Li, Huang Lv, Zhang Xiao-gang. Effect of surface electric-impulse stimulation on cardiac electrical activity of Kunming mice[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(27): 4318-4323.

Figures/Tables 8

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